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Seven Percent of Patients Taking Sulfa Antibiotics Have Adverse Reactions Approximately 6-8% of patients who take these drugs have adverse skin reactions ranging from a measles-like rash, hives and swelling, to severe life-threatening skin blistering conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis

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31 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Reversible metabolism via in vivo cleavage deconjugation of acyl glucuronides in systemic circulationZomepirac Liu and Smith, Current Drug Metabolism, 2006 Acyl glucuronides can be very labile once produced and exposed to hydrolases in vivo