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Patients should be monitored for any adverse reactions, and adjustments in dosage may be made based on individual response and tolerance

TP is in a liquid state at room temperature, enabling aerosolisation, while it undergoes a phase transition at the physiological temperature to form a hydrogel with a mucoadhesive characteristic that increases the nasal drug residence time, enhancing drug bioavailability

Diotallevi et al., 2017)

Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats