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We further determined the impact of ERMCS-localised GLP-1R signalling on -cell function by analysing acute insulin secretion responses and -cell survival to ER stress downstream of GLP-1R stimulation in SPHKAP RNAi-treated versus Control WT INS-1 832/3 cells

Abrupt discontinuation is generally safe from a pharmacological standpoint, as semaglutide does not cause physical dependence or withdrawal symptoms

It incorporates specific amino acid substitutions and terminal modifications designed to enhance molecular stability and receptor selectivity in experimental settings