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Int J Biol Macromol 137:346357 Lee J, Lim JW, & Kim H (2022) Lycopene inhibits IL-6 expression by upregulating NQO1 and HO-1 via activation of Nrf2 in ethanol/lipopolysaccharide-stimulated pancreatic acinar cells

These neuroprotective effects are attributed to vitamin Ds ability to influence the production and release of neurotrophins, support neurotransmitter synthesis, maintain intracellular calcium homeostasis, and prevent oxidative damage to nervous tissue (53)

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Proanthocyanidins also decrease histamine release from cells by inhibiting several other enzymes