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Within this realm, approaches dedicated to GSH depletion primarily encompass severing the supply of raw materials for GSH synthesis, inhibiting GSH synthesis, depleting GSH reserves, and facilitating GSH efflux [16]
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Kishi et al
She prefers her B12 in the form of an IV drip
AOD-9604 has been through human clinical study, which distinguishes it from many peptides in this category
The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity
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