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The model is based on known properties of the enzymes and the regulation of those enzymes by oxidative stress

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Studies in diabetic and insulin-resistance paradigms often use IGF-1 and its analogues to better understand how insulin demand and glucose homeostasis can be influenced at the receptor and signaling level

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Evaluation of the Effect of Sodium-Glucose Co-Transporter 2 Inhibition With Empagliflozin on Morbidity and Mortality of Patients With Chronic Heart Failure and a Reduced Ejection Fraction: Rationale for and Design of the EMPEROR-Reduced Trial