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As user data accumulates, clinical observations are used to refine protocols
ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB
These pharmacologic distinctions account for the observed efficacy differences and potential complexity when switching between the two
That inversion is the entire justification for a slow ladder: it front-loads the adaptation so the maintenance phase is comparatively smooth
However, it is important to note that dose increases are not mandatory and should only be done if you are tolerating your current dose well
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