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Buena parte de ese cambio puede atribuirse a la irrupcin de la semaglutida , un medicamento aprobado en 2021 para el tratamiento de la obesidad y que, pese a su alto costo y limitada disponibilidad, ha demostrado ser extraordinariamente eficaz

[1] [5] While GLP-1 receptors have variable distribution in reproductive tissues, the metabolic changes induced by GLP-1 agonists can have downstream effects on the hypothalamic-pituitary-ovarian axis, which governs menstrual function

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We also analyzed whether the agonists would differ in their propensity to remain bound to GLP-1R in endosomes