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Supplements in the form of pills and capsules can be difficult to swallow, and there is no guarantee that they will be broken down and absorbed in the digestive process, which is also impaired in Parkinsons patients

Clinicopathological implications

Fatigue is actually listed as a common adverse reaction in the Summary of Product Characteristics (SmPC) for some GLP-1 receptor agonists, particularly those used at higher doses for weight management such as semaglutide 2.4mg (Wegovy) and liraglutide 3mg (Saxenda)

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Compounded semaglutide uses the same active ingredient as FDA-approved products but is prepared by compounding pharmacies rather than the original manufacturer