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The effects of GLP-1 therapies extend well beyond pharmacological appetite suppression

Many literatures proved that GLP-1 derivatives performed neuroprotective effects and inhibited neuronal apoptosis ( Figure 1 There are also a type of non-peptide small molecules, which are mainly extracted from herbal medicine, such as Cornus officinalis , Gardenia jasminoides , Rehmannia glutinosa , Lamiophlomis rotata , and Strychnos nuzi ( Even for patients without complications of diabetes, their cognitive functions were still significantly improved ( 3 The neuroprotection of GLP-1RA in experimental stroke Many literatures indicated that GLP-1RA were also considered as the latent intervention strategy against ischemic stroke to improve the pathological symptoms and prognosis

S., Amaro, A., et al

Free Radical Biology and Medicine, 93, 110117

J Endocrinol Metab 25:283292