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Therefore, in this study, we attempted to clarify if GLP-1 analog shows reduction of body weight in POMC-MC4R deficiency using MC4R KO mice

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Both doses led to an increase in maximal respiration and ATP-linked respiration in HC cells, while mitochondrial biogenesis and oxidative phosphorylation gene expression remained unchanged, suggesting that UA specifically enhances mitochondrial respiration to improve chondrocyte metabolic function

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