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Protein also has a higher thermic effect of food (20-30% of calories consumed) compared to carbohydrates (5-10%) or fats (0-3%), meaning the body expends more energy digesting and metabolizing protein

BW change was also a secondary outcome of the SURMOUNT OSA 38 and the SYNERGY-NASH trial 39

Gastrointestinal Reactions (Reported/Theoretical) : Some reports suggest possible nausea or digestive discomfort, although consistent human data are lacking

Theranostics Li Y, Li M, Liu L, Xue C, Fei Y, Wang X, Zhang Y, Cai K, Zhao Y, Luo Z (2022) Cell-specific metabolic reprogramming of tumors for bioactivatable ferroptosis therapy

The primary difference lies in their mechanism of action