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This includes confirmed low serum vitamin B12 levels, pernicious anaemia, malabsorption states such as coeliac disease, inflammatory bowel disease, or post-gastric or bariatric surgery, unexplained anaemia, neuropathy or neurological symptoms consistent with vitamin B12 deficiency, a long-term vegan diet with symptoms or low levels, or failure of oral vitamin B12 supplementation
It is the main consumer of NAD + in aged tissues its activity increases significantly after age 40
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MTHFR mutations greatly inhibit the bodys ability to perform detox functions and lead to wide-ranging symptoms from headaches to infertility