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Additionally, EVs derived from steatotic hepatocytes or lipid-laden muscle cells have been shown to carry specific lipid cargo (e.g., ceramides) and microRNAs that can be delivered to recipient cells, such as vascular smooth muscle cells, promoting their phenotypic switch to a pro-calcific, pro-inflammatory state, thereby accelerating atherosclerotic plaque maturation and instability (101, 102)

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2021 Dec 26;12(12):CD010117