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Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors

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We thank Christopher Koscher for his assistance with protein expression and purification and Florian Grebien for help with establishing the RPE-1 cell lines stably expressing p53 and p53 mutants

The most direct starting point is the comprehensive TBI Hormone Panel based on Gordons neuroendocrine framework

These are associations rather than proof that altering NNMT activity reverses metabolic changes, but they motivate continued research into NNMT inhibitors in metabolic models