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Notably, disulfide bonds at Cys149-Cys189 and Cys177-Cys201 residues could be potential targets of LASSS modification/remodeling

And I know you're familiar with Nrf2, but Nrf2 is like your transcription factor

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Br J Nutr 1989

Also, people with diabetes who take a medication called metformin are at a higher risk of developing B12 deficiency because this medication can reduce B12 absorption