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Several phytochemicals, including berberine and other isoquinoline alkaloids, inhibit the assembly and activation of NLRP3, reducing mature pro-inflammatory cytokine release and mitigating neuroinflammation and neuronal loss in PD models ( Beyond immunomodulation, many plant phytoconstituents exert antioxidant and mitochondrial protective effects that are crucial in neurodegeneration

Wang S, Yin H, Huang Y, Guan X

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A one-month supply costs around $1,000 or more in the US without insurance