To test a general applicability of this mechanistic model, we confirmed our findings for the non-related enzyme PfGrx from the malaria parasite Plasmodium falciparum 18,33
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The main molecular mechanisms involved in the modulation of eryptosis studied to date, including intracellular calcium levels, ceramide, ROS, NO, changes in cellular energy metabolism, PS externalization, ion channel regulation, Fas-mediated signaling pathways, kinase-associated, and caspases activation, among others represent potential targets for inducing or inhibiting erythrocyte death