Safety analysis The incidence of adverse events in the two arms will be compared using the Pearson Chi-squared test or Fishers Exact test as required
Although pernicious anemia, or Addison-Biermer disease, had been recognized clinically in the mid-19th century, the associated neurologic, gastrointestinal, and hematologic manifestations were not recognized clinically and linked with pernicious anemia until the end of the 19th century (139)
If stopping mid-cycle due to side effects or logistical constraints, taper isnt necessarysimply discontinue both compounds and allow the standard washout period before restarting
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