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Overnight hypoglycemia is one of the more common mechanisms, especially in patients with type 2 diabetes on insulin or sulfonylureas, or in patients who skip dinner because of nausea
Maximizing benefits and managing side effects of GLP-1s When GLP-1s are prescribed, starting on a small dose and slowly increasing it can help minimize GI-related side effects and help patients manage them if they do occur
However, three safety considerations matter: (1) L-carnitine may lower blood sugar in susceptible individuals, potentially amplifying tirzepatide's glucose-lowering effect and requiring dose monitoring
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