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Antioxidants & redox signaling 20 , 574588, doi: 10.1089/ars.2012.5116 (2014)

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This is the crux of the dosing question: the failure to replicate cannot be attributed to underdosing relative to the original protocol, because the dose was matched

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In vitro and animal-model studies have examined its association with cytoskeletal organization, nitric-oxide-related signaling, angiogenesis-related mechanisms, and cellular adaptation under physiological stress