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However, it was not found to be statistically significant which might be due to low sample size (n = 3) in this group

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Notably, RSL3 is widely used as a pharmacological inhibitor of GPX4, although studies in cell-free systems suggest that it may also exhibit inhibitory activity toward thioredoxin reductase 1 (TXNRD1), a key NADPH-dependent antioxidant enzyme that maintains thioredoxin-mediated redox homeostasis

Individuals who may be at greater risk include: Those with a pre-existing diagnosis of osteoarthritis, rheumatoid arthritis, or other inflammatory joint conditions Patients with obesity-related joint loading, particularly affecting the knees, hips, and lower back Older adults, in whom musculoskeletal complaints are more prevalent at baseline Individuals experiencing rapid weight loss, which may transiently alter joint mechanics and gait, particularly in the lower limbs this is a theoretical consideration based on general musculoskeletal principles rather than retatrutide-specific evidence Significant weight reduction one of retatrutide's primary therapeutic effects is generally associated with reduced mechanical load on weight-bearing joints , which may improve joint symptoms over time in individuals with obesity-related arthropathy

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