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Drugs such as cocaine and nicotine lead to a much larger surge of dopamine, which strongly reinforces the link between consuming the drug and the pleasure that results

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People with type 2 diabetes , high blood pressure, high cholesterol, obstructive sleep apnea, smoking, and certain optic nerve anatomical features are known to have a higher risk of developing the condition (2 Trusted Source Ischemic Optic Neuropathies Go to source)

Both are dominated by mostly mild-to-moderate gastrointestinal effects, but the labeling differs