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HIGHLIGHTS OF PRESCRIBING INFORMATION: OZEMPIC (semaglutide) injection, for subcutaneous use

However, in individuals with type 2 diabetes, infusions of GIP(3-30)NH 2 reduced glucagon concentrations (78), illustrating the potential of GIP receptor antagonism to limit the paradoxical postprandial hyperglucagonemia in individuals with type 2 diabetes (93)

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doi: 10.1016/j.cca.2007.01.026 254 ShafieiMSShettySSchererPERockeyDC

First clinical trial to investigate the efficacy and safety of combined SGLT2 inhibitor and GLP-1R agonist therapy in patients with T2DM, suggesting additive or synergistic effects on weight loss