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A substantial body of previous research has indicated a correlation between low levels of vitamin D and an increased likelihood of experiencing symptoms associated with depression and anxiety [2, 3]

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Cysteine and glycine are generated from methionine and serine, respectively, and glutamic acid is synthesized from -ketoglutarate, a metabolite of glucose

Where available, documentation may include third-party testing references and COA information for batch-level verification

Gene silencing using siRNA and Western blot protocols are described in the Supplemental Methods, as is the use of streptavidin affinity pull-down of biotinylated peptides and MS