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One way to think about the thermic effect of food is that it represents the energy expenditure increase from baseline within the first 3-4 hours of eating a meal

A significant contributing factor to the prevalence of T2DM is obesity, which is strongly associated with serious consequences such as chronic kidney disease, hypertension, stroke, and liver disease that impair both the quality and quantity of life as life expectancy declines with rising body mass index (BMI) [2]

This timeline differs from Trulicitys more modest weight loss, highlighting another aspect of Mounjaro vs Trulicity effectiveness

Acids 31 , 211223 (2023)

Clinical trials have demonstrated weight loss ranging from approximately 10% with GLP-1 agents at weight management doses (e.g., semaglutide 2.4 mg in the STEP trials) to over 20% with tirzepatide at higher doses (SURMOUNT trials)