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The knockout of ATM can also lead to an increase in H 2 O 2 within HSCs and induce excessive proliferation and differentiation of HSCs through the activation of the p38-MAPK pathway, ultimately leading to HSC exhaustion [294]

Hirono A, Beutler E

If they are, RWD has the potential to enrich RCT data by providing first-hand baseline data, filling in missing data or by subgrouping or matching individuals, which calls for advanced methods to mitigate the differences between datasets

Therefore, the following supplemental tables present key studies that highlight the major roles of CHAC proteins (Supplementary Tables S1S6)

Does Glutalight Vitamin C Serum have anti-ageing properties