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There is one open-label intravenous safety pilot in two healthy adults, who received single doses of 10 mg and 20 mg with no comparator, no blinding, and short-term observation limited to vital signs, self reported symptoms and labs across two days [4]

Due to narrow therapeutic windows resulting from limited MC3R/MC4R activity, suboptimal pharmacokinetics, and intolerable side effects, none were deemed efficacious in general obesity

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