Figure 1: Folate metabolism starts with polyglutamate folates (a form of Vitamin B9), which are broken down by the enzyme dihydrofolate reductase (DHFR) into dihydrofolate and then tetrahydrofolate (THF)
It appeals to consumers seeking: Antioxidant protection Dullness correction Radiance enhancement Urban pollution defence Its association with cellular health gives it strong appeal in premium skincare segments
Rarely reported side effects include: Allergic reactions, leading to a rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing
Limiting portions of high-protein foods such as red meat, poultry, eggs, dairy products, and fish is generally recommended to help preserve kidney function
It is worth noting that histological examination of the liver revealed no significant liver inflammation in either WT or KO mice (Fig