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qRT-PCR analysis (Figure 2E) showed that FOXO4-DRI-treated PDL9 cells displayed enhanced SOX9 expression, and reduced MMP12 and MMP13 expression, which however were at the expense of lower expression levels of COL2

Any study that appeared to meet the predefined eligibility criteriaoutlined in Table 1 and focused on the role of GLP-1 agonists in body weight regulation and neuroprotection, was selected for further evaluation and full-text review

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A better way to look at it is, if you stop the medication but continue with other behavioral changes like a healthy diet and exercise, you would not gain the weight back