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In AD, oxidative stress causes significant protein oxidation, impacting their structure and function [20]

Data analysed by two-way repeated measures ANOVA to assess main effect effects of treatment ( b , c , f , g , j , k and m ) and two-way ANOVA, multiple comparison, Bonferroni post hoc test ( h )

These metabolic changes were supported by alterations in the gene expression of choline metabolism-related enzymes, such as choline dehydrogenase ( Chdh ), betaine-homocysteine methyltransferase ( Bhmt ), and DMG dehydrogenase ( Dmgdh ), and glycerophosphocholine phosphodiesterase 1 ( Gpcpd1 )

The therapeutic window for inhibiting GGT as a cancer therapy is potentially large, as sustained inhibition of GGT activity did not induce any overt toxicities

& Kim, Y.G