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All this came back to become critical in the fragment condensation approach because you have the possibility to form nitrosamine and this type of genotoxic impurity during the fragment condensation, added Villain

[7] In isolated perfused colon, butyrate and propionate dose-dependently stimulated GLP-1 secretion, [8] and studies in human enteroendocrine cells confirmed that SCFAs drive gut-hormone production in human (not just rodent) tissue