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To groups of five anaesthetized rats, peptides (exenatide or semaglutide) in sterile Dulbeccos phosphate buffer saline (DPBS) (Biowest, L0615) were administered by intravenous injection via the tail vein

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Similar exposure was achieved with subcutaneous administration of tirzepatide in the abdomen, thigh, or upper arm

A supplemental new drug application (sNDA) for Rybelsus to reduce the risk of MACE in people with T2DM and established CVD and/or CKD is awaiting an FDA decision