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Inject subcutaneously at a clean, rotated site abdomen, thigh, or upper arm For how to manage any side effects during titration, see our [semaglutide side effects guide](/guides/semaglutide-side-effects-how-to-manage)

Serious reactions are extremely rare, especially when injections are performed by licensed medical professionals

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I've seen how vitamin b complex shots can support energy levels and overall health when used as part of a personalized wellness plan

The exception to this rule is the single preparation of the sub-Q or IM dose that exceeds the volume safely injected at a single site