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(2007) Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress

When nutrients arrive in the lower intestine, L-cells activate this conversion process

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Because the peptide typically peaks and declines within a few hours, spacing injections at least 24 hours apart tends to reduce stacking of acute side effects like nausea, flushing, and blood pressure swings