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Research in Drosophila melanogaster demonstrated geroprotective effects at concentrations 16,000-80,000,000 times lower than those required for melatonin, suggesting Epithalon functions through highly efficient regulatory mechanisms rather than stoichiometric antioxidant consumption

Blood pressure showed a non-significant trend toward reduction in aortic stiffness, a finding that has not been replicated at scale

These findings indicate that MEPP can effectively inhibit NO formation in vitro and may hold considerable potential for preventing the deleterious effects of NO in vivo 13,14,41

Importantly, animal reproductive toxicity does not necessarily predict human outcomes , and the mechanisms observed in these studies may not translate directly to human physiology