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In addition, the enteric nervous system (ENS), which is a recognized second brain that can regulate many GI functions independent of CNS action, can also act as an intermediate in relaying gut-derived information to the CNS 25

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For tirzepatide in the SURMOUNT-1 trial, nausea rates ranged from 25-33% depending on the dose, with higher doses associated with increased incidence

They combine high sugar with refined flour and often significant fat content

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