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ELs elevated tail moment, despite lacking active drug, demonstrates that lipid vehicles contribute directly to genotoxicity via endocytosis-mediated membrane disruption and transient ROS generation

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Brooks AJ, Fox CC, Marsh ENG, Vlasie M, Banerjee R, Brunold TC

For instance, the release of damage-associated molecular patterns (DAMPs) such as HMGB1 during ferroptosis activates receptors like AGER/RAGE, stimulating the NF-B pathway (Wen et al., 2019)

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