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Its role in reproduction was discovered in 2003 when mutations in its receptor (KISS1R/GPR54) were found to cause hypogonadotropic hypogonadismfailure of puberty and reproductive function

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) receptor agonists mark a significant breakthrough in diabetes and obesity management, significantly aiding in weight loss and glycemic control

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MC3/4R activation reduces food intake in rodent models, though the effect tolerates with repeated dosing

Welcome Back Rheumatology Fans, 2026 The year of the GLP-1 Agonist