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Recent study has shown that the novel P2Y12 receptor antagonist, Ticagrelor upregulated the expression of phosphorylated eNOS and alleviated ER stress in the rat aortic endothelial cells, however this effect can be reversed by ER stress inhibitors

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This process happens in both the cytosol and mitochondria

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They include: Pain, redness, or swelling at the injection site Mild diarrhea or nausea Itching or skin irritation near the injection area A sensation of swelling throughout the body Headache or dizziness These effects typically resolve within 24 to 48 hours and do not require medical intervention