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50 Inhibition of KLF15 also leads to reduced expression of PPAR, blocking adipogenesis in 3T3-L1 preadipocytes
According to NICE Clinical Knowledge Summary guidance, patients with neurological involvement should receive more intensive initial treatment to optimise recovery potential
Persistent unexplained elevation alongside an abnormal CBC or differential, constitutional symptoms such as unexplained weight loss, night sweats, or persistent fever, or organ-specific findings all raise the need for referral
Difficulty concentrating and impaired memory: These may indicate a Vitamin B12 deficiency, which can also lead to mental health issues like depression and behavioral changes
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