Litten RZ, Wilford BB, Falk DE, Ryan ML, Fertig JB
00:11:38 Vickie Danaher In addition to switches, we want to watch for patients combining oral and injectable GLP-1 agonists
Deficiency is common, especially in people who follow a vegetarian or vegan diet
The sexual function effects of MT-2 are centrally mediated through hypothalamic melanocortin circuits, not through peripheral vascular mechanisms, which distinguishes MT-2 from PDE5 inhibitors and explains its effectiveness in patients where desire and arousal motivation, rather than vascular mechanics, is the limiting factor
Cocaine Only limited clinical evidence is available for GLP-1RAs in cocaine misuse: a small ( N = 13) proof-of-concept trial across 2 days showed that exenatide compared with placebo did not reduce the number of self-administered cocaine infusions 115 , while a case series of 3 individuals with cocaine-use disorder highlighted the feasibility and safety of using the same drug over 6 weeks, although no efficacy measures were reported 116