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Inclusion criteria: Articles were included if the study used GLP-1/GLP-1 receptor agonists, discussed whether or not they penetrated the CNS/brain indirectly or directly, the age range was 1880 years old for human studies, and the studies were original articles

People taking insulin injections may have constipation, and those taking semaglutide injections may experience nausea, vomiting, diarrhea, and stomach pain

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Iron accumulation also promotes oxidative stress, destroys cell membranes, and induces ferroptosis