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Furthermore, the extract upregulated the expression of aquaporin 5 (AQP5) in the lacrimal glands and inhibited the activation of MAPK and NF-B signaling pathways, leading to decreased production of pro-inflammatory cytokines [89]
What is ochronosis, and why does it only happen with hydroquinone? Exogenous ochronosis is a paradoxical darkening of the skin caused by hydroquinone metabolite accumulation in dermal collagen fibres, producing blue-black discolouration that worsens with continued use
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Pairwise Euclidean distances were computed between diseases based on their Reactome pathway enrichment profiles (using normalized enrichment scores from GSEA)
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