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Formulary modeling requires drug utilization data, price data, clinical equivalence data, and patient-level cost sensitivity analysis (because the impact of a formulary change varies substantially depending on how patients in the plan are distributed across deductible, cost-sharing, and out-of-pocket maximum thresholds)
However, several data points help explain just how widespread the issue appears to be: Clinical Trial Data : In Novo Nordisk clinical trials, about 9% of patients reported frequent burping (officially known as eructation)a wellknown pathway for odor to reach the breath
10.1111/dom.12291 160 ZhongW.ZhaoY.TangY.WeiX.ShiX.SunW.et al (2012)
Unlike statins, these medications do not have known myotoxic effects on muscle cells
Oncogene 32:40434051
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