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Disclosed by Eli Lilly investigators in 2022 under the development code LY3437943, retatrutide builds conceptually on the dual-incretin foundation established by tirzepatide while extending receptor engagement to include the glucagon receptor, a pharmacological pathway that earlier incretin research had largely avoided due to concerns about hyperglycemia and lipolysis

doi: 10.1016/j.bbagen.2014.03.007 85 DengSHuBShenKPXuL