In obese patients, acipimox can inhibit adipose tissue lipolysis by activating protein upregulated in macrophage by INF- (PUMA-G) (also known as the hydroxycarboxylic acid receptor 2 [HCA2] and GPR109a) receptors
Who should administer it?+ It is for administration by trained medical professionals only, after assessing patient suitability
People who are otherwise healthy may be less willing to accept these potentially serious adverse events. Using a random sample of 16 million patients from the PharMetrics Plus database, Sodhi and colleagues evaluated gastrointestinal adverse events among new users of GLP-1 agonists liraglutide (n = 4,144) or semaglutide (n = 613) between 2006 and 2020
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