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With sufficient glutathione present, NAPQI is very quickly metabolized into sulfate and cysteine compounds, which are readily excreted through the kidneys.[ref] However, when it isnt neutralized, NAPQI is highly reactive and can cause oxidative stress and damage to the liver cells, hepatocytes, leading to cell death
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PMID 15671130
Gclc L-KO mice showed no overt histological signs of liver damage (Fig
10.1016/j.ijcard.2007.01.004 10 Chinese Pharmacopoeia Commission Pharmacopoeia of the Peoples Republic of China (2020) Chinese Pharmacopoeia commission Pharmacopoeia of the Peoples Republic of China , 1
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