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Am J Physiol Renal Physiol

They work through different mechanisms and can produce synergistic effects

There is not as much evidence regarding long-term efficacy or safety of gel vitamin B12 compared to injections, but at this time it appears B12 gel works similarly to raise blood levels

But because there arent published human clinical trials on KPV, we simply dont yet know how this translates to humans, what dosing ranges are best, or whether it's safe over the long term