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According to clinical trial data for semaglutide: nausea (up to 44% of patients) and diarrhoea (~30%) are the top complaints , followed by vomiting (~24%), constipation, and general stomach discomfort

In an extensive phase III clinical program including patients from across the disease spectrum, treatment with oral semaglutide resulted in effective glycemic control, reductions in body weight, and decreases in systolic blood pressure when used as monotherapy or in combination with other glucose-lowering therapies

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